Title : Sequential activation of classic PKC and estrogen receptor α is involved in estradiol 17ß-D-glucuronide-induced cholestasis.

Pub. Date : 2012

PMID : 23209816






1 Functional Relationships(s)
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1 In PRL, E17G maximally decreased bile flow, and the excretions of dinitrophenyl-glutathione, and taurocholate (Abcc2 and Abcb11 substrates, respectively) by 60% approximately; preadministration of ICI 182,780 (ICI, ERalpha inhibitor) almost totally prevented these decreases. Taurocholic Acid ATP binding cassette subfamily C member 2 Rattus norvegicus