Title : PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.

Pub. Date : 2012 Nov 28

PMID : 23197723






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The PPARgamma agonist pioglitazone and a novel selective PPARalpha/gamma modulator, DSP-8658, currently in clinical development for the treatment of type 2 diabetes, enhanced the microglial uptake of Abeta in a PPARgamma-dependent manner. Pioglitazone amyloid beta (A4) precursor protein Mus musculus