Title : Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells.

Pub. Date : 2010 Dec

PMID : 23181152






3 Functional Relationships(s)
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1 The ocular cancer, retinoblastoma cells were treated with fatty acid synthase (FASN) enzyme inhibitors: cerulenin, triclosan and orlistat. Cerulenin fatty acid synthase Homo sapiens
2 The ocular cancer, retinoblastoma cells were treated with fatty acid synthase (FASN) enzyme inhibitors: cerulenin, triclosan and orlistat. Cerulenin fatty acid synthase Homo sapiens
3 The crystal structures of ketoacyl synthase (PDB ID:3HHD) (cerulenin) and thioesterase (PDB ID:2PX6) (orlistat) domains of human FASN were utilized for docking, while for the non-crystallised human FASN enoyl reductase domain (triclosan), homology model was built and used for docking. Cerulenin fatty acid synthase Homo sapiens