Title : ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Pub. Date : 2012 Dec

PMID : 23178880






1 Functional Relationships(s)
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1 Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1. Serine mitogen-activated protein kinase 1 Homo sapiens