Title : SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells.

Pub. Date : 2013 Jan 4

PMID : 23178716






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells. Arsenic Trioxide AKT serine/threonine kinase 1 Homo sapiens
2 As2O3 activates Src(Y416) whose activity (inhibited by PP2) modulates EGFR activation, its interaction with Shc/Grb2, and p-AKT. Arsenic Trioxide AKT serine/threonine kinase 1 Homo sapiens
3 Collectively, As2O3 mediates an initial rise in pY-Src(416) to regulate the PI3K/AKT pathway which increases SnoN and cell survival; these early events may counter the cell death response associated with increased pY-EGFR/MAPK activation. Arsenic Trioxide AKT serine/threonine kinase 1 Homo sapiens