Pub. Date : 2013 Jan 4
PMID : 23178716
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | As2O3 activates Src(Y416) whose activity (inhibited by PP2) modulates EGFR activation, its interaction with Shc/Grb2, and p-AKT. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Collectively, As2O3 mediates an initial rise in pY-Src(416) to regulate the PI3K/AKT pathway which increases SnoN and cell survival; these early events may counter the cell death response associated with increased pY-EGFR/MAPK activation. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |