Title : Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation.

Pub. Date : 2013 Feb 1

PMID : 23174566






4 Functional Relationships(s)
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1 Our previous results led us to hypothesize that EPA and DHA alter the ability of platelets to catalyze the generation of thrombin. Eicosapentaenoic Acid coagulation factor II, thrombin Homo sapiens
2 Platelets treated with EPA and DHA showed reductions in the rate of thrombin generation and exposure of platelet phosphatidylserine. Eicosapentaenoic Acid coagulation factor II, thrombin Homo sapiens
3 In addition, treatment of platelets with EPA and DHA decreased thrombus formation and altered the processing of thrombin precursor proteins. Eicosapentaenoic Acid coagulation factor II, thrombin Homo sapiens
4 These results demonstrate that EPA and DHA inhibit, but do not eliminate, the ability of platelets to catalyze thrombin generation in vitro. Eicosapentaenoic Acid coagulation factor II, thrombin Homo sapiens