Pub. Date : 2013 Feb
PMID : 23172666
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that BITC not only induces apoptosis but also induces autophagy in human hormone-sensitive (Rv1) and -refractory (PC3) prostate cancer cells. | benzyl isothiocyanate | proprotein convertase subtilisin/kexin type 1 | Homo sapiens |
| 2 | However, the increased expression of phospho-mTOR (Ser2448), phospho-AKT (Ser473) and antiapoptotic Bcl-2 were detected only in PC3 cells at later stages of BITC treatment. | benzyl isothiocyanate | proprotein convertase subtilisin/kexin type 1 | Homo sapiens |
| 3 | Activation of the AKT survival pathway was only observed in PC3 cells, representing a resistance mechanism of advanced prostate cancer upon BITC treatment. | benzyl isothiocyanate | proprotein convertase subtilisin/kexin type 1 | Homo sapiens |