Pub. Date : 2013 Jan
PMID : 23167625
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We studied the relation between sensitivity to celecoxib and the phenotypic p53 status of PCa cells lines, LNCaP (wild type p53), PC3 (null p53) and DU145 (mutated p53). | Celecoxib | tumor protein p53 | Homo sapiens |
| 2 | The effects of celecoxib on cellular growth and its association with p53 were assessed after down-regulation of p53 using synthetic interfering RNAs (siRNA) in LNCaP cells. | Celecoxib | tumor protein p53 | Homo sapiens |
| 3 | We found that celecoxib inhibited cellular growth and proliferation in a dose-dependent manner in all three cell lines; LNCaP cells with a native p53 were the most sensitive to celecoxib. | Celecoxib | tumor protein p53 | Homo sapiens |
| 4 | We observed a down- regulation effect on p53 in LNCaP cells exposed to >= 30 muM celecoxib for 72 h, but found no significant changes in the p53 levels of DU145 cells, which have a mutated p53. | Celecoxib | tumor protein p53 | Homo sapiens |
| 5 | Reduced COX-2 expression was found with decreased p53 in LNCaP and PC-3 cells that were exposed to >= 20 muM of celecoxib for 72 h, but COX-2 expression was increased in DU145 cells. | Celecoxib | tumor protein p53 | Homo sapiens |
| 6 | When p53 expression was inhibited using siRNA in LNCaP cells, the inhibitory effects on cellular growth usually exerted by celecoxib were not changed significantly. | Celecoxib | tumor protein p53 | Homo sapiens |