Title : Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.

Pub. Date : 2012

PMID : 23166498






2 Functional Relationships(s)
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1 We show that all of the anti-HCV ribonucleoside analogues are substrates for human mitochondrial RNA polymerase (POLRMT) and eukaryotic core RNA polymerase II (Pol II) in vitro. Ribonucleosides RNA polymerase mitochondrial Homo sapiens
2 Evaluation of transcription in cells confirmed sensitivity of POLRMT to antiviral ribonucleosides, while Pol II remained predominantly refractory. Ribonucleosides RNA polymerase mitochondrial Homo sapiens