Title : Testosterone exerts selective anti-inflammatory effects on human skin mast cells in a cell subset dependent manner.

Pub. Date : 2012 Nov

PMID : 23163656






1 Functional Relationships(s)
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1 While fundamental MC properties (FcepsilonRI, c-Kit, tryptase; histamine release upon FcepsilonRI cross-linking) were unaffected or slightly reduced (chymase) by testosterone, the hormone had a more profound impact on the production of cytokines, with IL-6 being a target (reduction by 53%). Histamine Fc epsilon receptor Ia Homo sapiens