Title : Ibuprofen: from invention to an OTC therapeutic mainstay.

Pub. Date : 2013 Jan

PMID : 23163543






1 Functional Relationships(s)
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1 Ex vivo inhibition of COX-1 (thromboxane A(2)) and COX-2 (PGE(2)) at the plasma concentrations of S(+)-ibuprofen corresponding to those found in the plasma following ingestion of 400 mg ibuprofen in dental and other inflammatory pain models provides evidence of the anti-inflammatory mechanism at OTC dosages. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens