Pub. Date : 2012 Jul
PMID : 23156727
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The changes of protein kinase A were measured in central amygdaloid nucleic (CeA) of conditioned place aversion (CPA) model rats. | cpa | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 2 | (2) During the process of morphine-induced CPA, the expression of protein kinase A was assayed with immunohistochemistry in the CeA. | cpa | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 3 | RESULTS: In the MN group, protein kinase A expressions in the CeA occurred adaptive changes at different points of CPA (P < 0.05). | cpa | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 4 | Protein kinase A expressions after establishment(Day7,134.43 +/- 4.481, P < 0.05), and after extinction (Day 13, 141.01 +/- 3.360, P < 0.01), and after reinstatement (Day 14,137.18 +/- 40.330, P < 0.05) were also lower than those before the establishment of the CPA (Day 5, 124.48 +/- 6.722). | cpa | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 5 | CONCLUSION: (1) Protein kinase A expression, in turn regulating the aversion expression, in the CeA probably is a key pathway contributing to the development of CPA. | cpa | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |
| 6 | (2) The neuroadaptation mediated by protein kinase A may be one of the important molecular underpinnings of CPA. | cpa | protein kinase cAMP-activated catalytic subunit alpha | Rattus norvegicus |