Pub. Date : 2013 Jun
PMID : 23149816
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clopidogrel is a prodrug which requires a two-step hepatic biotransformation thanks to the cytochrome P450 (CYP450) enzyme system. | Clopidogrel | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | Clopidogrel is a prodrug which requires a two-step hepatic biotransformation thanks to the cytochrome P450 (CYP450) enzyme system. | Clopidogrel | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Genetic polymorphism of CYP450 system (e.g., CYP2C19*2) responsible for altered clopidogrel metabolism is a major cause of high on-treatment platelet reactivity (HTPR), which translates into thrombotic events in stented patients. | Clopidogrel | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |