Pub. Date : 2013 Feb
PMID : 23149278
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of the injured rats with the beta-catenin inhibitor ICG-001 (oral gavage at 200mg/kg/day for 8days, commenced at day 2 post injury) enhanced COL2A1 gene expression (by qRT-PCR) and increased proportion of cartilage tissue (by histological analysis), but decreased level of osterix expression and amount of bone tissue, at the injury site by day 10 post-injury (n=8, P<0.01 compared to vehicle controls). | Indocyanine Green | catenin beta 1 | Rattus norvegicus |
| 2 | Consistently, in vitro studies with bone marrow stromal cells from normal rats showed that beta-catenin inhibitor ICG-001 dose dependently inhibited expression of Wnt target genes Cyclin D1 and survivin (P<0.01). | Indocyanine Green | catenin beta 1 | Rattus norvegicus |