Title : Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.

Pub. Date : 2013 Jan 18

PMID : 23148211






8 Functional Relationships(s)
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1 We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR). Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
2 We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR). Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
3 We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR). Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
4 We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR). Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
5 We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR). Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
6 We previously found that overexpression of PDI in rat pituitary tumor (GH3) cells suppresses 3,3",5-triiodothyronine (T(3))-stimulated growth hormone (GH) expression, suggesting the contribution of PDI to the T(3)-mediated gene expression via thyroid hormone receptor (TR). Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
7 Overexpression of wild-type but not redox-inactive mutant PDI suppressed the T(3)-induced GH expression, suggesting that the redox activity of PDI contributes to the suppression of GH. Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus
8 Overexpression of wild-type but not redox-inactive mutant PDI suppressed the T(3)-induced GH expression, suggesting that the redox activity of PDI contributes to the suppression of GH. Triiodothyronine gonadotropin releasing hormone receptor Rattus norvegicus