Pub. Date : 2013 Sep
PMID : 23148031
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, the inhibition kinetic type and parameters were determined for the inhibition of glycyrrhetinic acid towards UGT1A3 and UGT2B7. | Glycyrrhetinic Acid | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 2 | Data fitting using Dixon and Lineweaver-Burk plots demonstrated that the inhibition of UGT1A3 and UGT2B7 by glycyrrhetinic acid was best fit to competitive and noncompetitive type, respectively. | Glycyrrhetinic Acid | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |
| 3 | The second plot using the slopes from Lineweaver-Burk plots versus glycyrrhetinic acid concentrations was employed to calculate the inhibition kinetic parameters (K(i)), and the values were calculated to be 0.2 and 1.7 muM for UGT1A3 and UGT2B7, respectively. | Glycyrrhetinic Acid | UDP glucuronosyltransferase family 2 member B7 | Homo sapiens |