Pub. Date : 2013 Apr
PMID : 23146110
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. | andrographolide | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Andrographolide has been shown to activate nuclear factor erythroid-2-related factor 2 (Nrf2), a redox-sensitive antioxidant transcription factor. | andrographolide | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Andrographolide has been shown to activate nuclear factor erythroid-2-related factor 2 (Nrf2), a redox-sensitive antioxidant transcription factor. | andrographolide | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | As Nrf2 activity is reduced in COPD, we hypothesize that andrographolide may have therapeutic value for COPD. | andrographolide | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | In BEAS-2B cells, andrographolide markedly increased nuclear Nrf2 accumulation, promoted binding to antioxidant response element (ARE) and total cellular glutathione level in response to CSE. | andrographolide | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 6 | CONCLUSIONS: Andrographolide possesses antioxidative properties against cigarette smoke-induced lung injury probably via augmentation of Nrf2 activity and may have therapeutic potential for treating COPD. | andrographolide | NFE2 like bZIP transcription factor 2 | Homo sapiens |