Title : Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Pub. Date : 2013 Jan 10

PMID : 23142078






1 Functional Relationships(s)
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1 We show that glucose and glutamine, by supplying carbons to the TCA cycle to produce ATP, positively feed back to mTORC1 through an AMPK-, TSC1/2-, and Rag-independent mechanism by regulating mTORC1 assembly and its lysosomal localization. Glucose TSC complex subunit 1 Homo sapiens