Title : (-)-Epigallocatechin 3-gallate inhibits invasion by inducing the expression of Raf kinase inhibitor protein in AsPC‑1 human pancreatic adenocarcinoma cells through the modulation of histone deacetylase activity.

Pub. Date : 2013 Jan

PMID : 23135610






2 Functional Relationships(s)
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1 The phosphorylation of ERK was decreased by RKIP induction following EGCG treatment. epigallocatechin gallate mitogen-activated protein kinase 1 Homo sapiens
2 Taken together, our results strongly suggest that EGCG regulates RKIP/ERK/NF-kappaB and/or RKIP/NF-kappaB/Snail and inhibits invasive metastasis in the AsPC-1 human pancreatic adenocarcinoma cell line. epigallocatechin gallate mitogen-activated protein kinase 1 Homo sapiens