Title : In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.

Pub. Date : 2013 Feb

PMID : 23132334






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 DTG does inhibit the renal OCT2 (IC(50) = 1.9 muM) transporter, which provides a mechanistic basis for the mild increases in serum creatinine observed in clinical studies. dolutegravir POU class 2 homeobox 2 Homo sapiens