Pub. Date : 2013 Jan
PMID : 23127783
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Herein, we investigated the roles and the possible mechanisms of leonurine for reducing fibrotic responses in angiotensin II (Ang II)-stimulated primary neonatal rat cardiac fibroblasts and post-myocardial infarction (MI) rats. | leonurine | angiotensinogen | Rattus norvegicus |
| 2 | Herein, we investigated the roles and the possible mechanisms of leonurine for reducing fibrotic responses in angiotensin II (Ang II)-stimulated primary neonatal rat cardiac fibroblasts and post-myocardial infarction (MI) rats. | leonurine | angiotensinogen | Rattus norvegicus |
| 3 | In in vitro experiments performed in neonatal rat cardiac fibroblasts, leonurine (10-20 muM) pretreatment attenuated Ang II-induced activation of extracellular signal-regulated kinase 1/2, production of intracellular reactive oxygen species (ROS), expression and activity of matrix metalloproteinase (MMP)-2/9, and expression of alpha-smooth muscle actin and types I and III collagen. | leonurine | angiotensinogen | Rattus norvegicus |