Title : The androgen metabolite, 5α-androstane-3β,17β-diol, decreases cytokine-induced cyclooxygenase-2, vascular cell adhesion molecule-1 expression, and P-glycoprotein expression in male human brain microvascular endothelial cells.

Pub. Date : 2012 Dec

PMID : 23117931






2 Functional Relationships(s)
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1 The principal metabolite of DHT, 5alpha-androstane-3beta,17beta-diol (3beta-diol), activates estrogen receptor (ER)beta and similarly decreases inflammatory markers in vascular cells. Androstane-3,17-diol estrogen receptor 1 Homo sapiens
2 Using RT-qPCR, the mRNAs for AR, ERalpha, and ERbeta and steroid metabolizing enzymes necessary for DHT conversion to 3beta-diol were detected in male HBMECs demonstrating that the enzymes and receptors for production of and responsiveness to 3beta-diol are present. Androstane-3,17-diol estrogen receptor 1 Homo sapiens