Title : Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility.

Pub. Date : 2012 Dec

PMID : 23117930






1 Functional Relationships(s)
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1 We have shown previously that transgenic female mice overexpressing human chorionic gonadotropin beta-subunit (hCGbeta+ mice), and producing elevated levels of bioactive LH/hCG, exhibit increased production of testosterone and progesterone, are overweight and infertile, and develop hyperprolactinemia associated with pituitary lactotrope adenomas in adult age. Progesterone chorionic gonadotropin subunit beta 5 Homo sapiens