Title : Hydroxylation of (-)-epigallocatechin-3-O-gallate at 3'', but not 4'', is essential for the PI3-kinase/Akt-dependent phosphorylation of endothelial NO synthase in endothelial cells and relaxation of coronary artery rings.

Pub. Date : 2013 Feb

PMID : 23104077






1 Functional Relationships(s)
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1 In contrast, the single methylation at position 3"" and the double methylation at both positions 3" and 4" reduced markedly the phosphorylation of Akt and eNOS, the formation of ROS and NO in endothelial cells and the relaxation of artery rings. Reactive Oxygen Species nitric oxide synthase 3 Homo sapiens