Title : Attenuation of biopterin synthesis prevents Escherichia coli K1 invasion of brain endothelial cells and the development of meningitis in newborn mice.

Pub. Date : 2013 Jan 1

PMID : 23100563






1 Functional Relationships(s)
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1 We demonstrate that Escherichia coli K1 infection of human brain microvascular endothelial cells (HBMECs) induces the expression of guanosine triphosphate cyclohydrolase (GCH1), the rate-limiting enzyme in pterin synthesis, thereby elevating levels of biopterin. Pterins GTP cyclohydrolase 1 Homo sapiens