Title : The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.

Pub. Date : 2012 Nov 30

PMID : 23086953






1 Functional Relationships(s)
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Protein Name
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1 SIRT6 increases the nuclear levels of the Ca(2+)-dependent transcription factor, nuclear factor of activated T cells (NFAT), and cyclosporin A, a calcineurin inhibitor that reduces NFAT activity, reduces TNF and IL8 expression in SIRT6-overexpressing cells. Cyclosporine sirtuin 6 Homo sapiens