Title : Association of CYP3A polymorphisms with the pharmacokinetics of cyclosporine A in early post-renal transplant recipients in China.

Pub. Date : 2012 Dec

PMID : 23085740






3 Functional Relationships(s)
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1 RESULTS: The CYP3A5*3C polymorphism influenced the C(0) and C(0)/dose of CsA, which were significantly higher in patients with the GG genotype than in patients with the AA or GA genotypes. Cyclosporine cytochrome P450 family 3 subfamily A member 5 Homo sapiens
2 In the multiple regression model, CYP3A5*3C, age, hemoglobin and blood creatinine level were associated with the log-transformed CsA C(0)/dose. Cyclosporine cytochrome P450 family 3 subfamily A member 5 Homo sapiens
3 CONCLUSION: CYP3A5*3C correlates with the C(0)/dose of CsA on the seventh day after renal transplantation. Cyclosporine cytochrome P450 family 3 subfamily A member 5 Homo sapiens