Title : Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453.

Pub. Date : 2013 Feb

PMID : 23085420






3 Functional Relationships(s)
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Protein Name
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1 In contrast, it was found that DHA as well as other PUFAs inhibited Akt phosphorylation on T308 after 24h. dehydroacetic acid AKT serine/threonine kinase 1 Homo sapiens
2 After 48h, only DHA inhibited Akt phosphorylation on the both residues. dehydroacetic acid AKT serine/threonine kinase 1 Homo sapiens
3 These results suggest that DHA suppressed the growth of the cancer cell through its specifically persistent block of Akt phosphorylation in conjunction with modulation of fatty acid metabolism. dehydroacetic acid AKT serine/threonine kinase 1 Homo sapiens