Title : Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulation of choline uptake.

Pub. Date : 2012 Oct 17

PMID : 23077721






2 Functional Relationships(s)
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1 We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators. Hemicholinium 3 solute carrier family 5 member 7 Homo sapiens
2 We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators. Hemicholinium 3 solute carrier family 5 member 7 Homo sapiens