Pub. Date : 2012
PMID : 23076128
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Imipramine induces brain-derived neurotrophic factor mRNA expression in cultured astrocytes. | Imipramine | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | In the present study, we evaluated the effects of imipramine, a classic tricyclic antidepressant drug, on BDNF expression in cultured rat brain astrocytes. | Imipramine | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | Imipramine dose-dependently increased BDNF mRNA expression in astrocytes. | Imipramine | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | The imipramine-induced BDNF increase was suppressed with inhibitors for protein kinase A (PKA) or MEK/ERK. | Imipramine | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | These results suggested that imipramine induced BDNF expression through CREB activation via PKA and/or ERK pathways. | Imipramine | brain-derived neurotrophic factor | Rattus norvegicus |
| 6 | Imipramine treatment in depression might exert antidepressant action through BDNF production from astrocytes, and glial BDNF expression might be a target of developing novel antidepressants. | Imipramine | brain-derived neurotrophic factor | Rattus norvegicus |