Title : Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6β-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects.

Pub. Date : 2013 Feb

PMID : 23073666






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 6beta-hydroxycortisol uptake was determined in HEK293 cells expressing OAT1, OAT3, OCT2, MATE1, and MATE2-K. 6 beta-hydroxycortisol solute carrier family 22 member 8 Homo sapiens
2 6beta-hydroxycortisol was a substrate of OAT3 (K(m) = 183 +- 25 mumol/l), OCT2, MATE1, and MATE2-K. 6 beta-hydroxycortisol solute carrier family 22 member 8 Homo sapiens