Pub. Date : 2013 Mar
PMID : 23052480
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results revealed a highly significant increase in IL-6 and cIAP-2 mRNA and protein levels upon treatment with cisplatin. | Cisplatin | interleukin 6 | Homo sapiens |
| 2 | WB analysis of cisplatin-treated cells exhibited decreased cIAP-2 expression level following anti-IL-6 Ab addition. | Cisplatin | interleukin 6 | Homo sapiens |
| 3 | Finally, cytotoxicity assays showed sensitization to cisplatin following the addition of IL-6 and cIAP-2 inhibitors. | Cisplatin | interleukin 6 | Homo sapiens |
| 4 | In conclusion, cisplatin treatment of ovarian carcinoma cells upregulates IL-6 and cIAP-2 levels while their inhibition significantly sensitizes them to cisplatin. | Cisplatin | interleukin 6 | Homo sapiens |
| 5 | Here, we present cIAP-2 as a novel inducer of platinum resistance in ovarian carcinoma cells, and suggest an axis beginning with an encounter between cisplatin and these cells, mediated sequentially by IL-6 and cIAP-2, resulting in cisplatin resistance. | Cisplatin | interleukin 6 | Homo sapiens |
| 6 | Here, we present cIAP-2 as a novel inducer of platinum resistance in ovarian carcinoma cells, and suggest an axis beginning with an encounter between cisplatin and these cells, mediated sequentially by IL-6 and cIAP-2, resulting in cisplatin resistance. | Cisplatin | interleukin 6 | Homo sapiens |