Pub. Date : 2012 Oct
PMID : 23045722
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel CaV2.2 channel inhibition by piracetam in peripheral and central neurons. | Piracetam | calcium voltage-gated channel subunit alpha1 B | Homo sapiens |
| 2 | In this study, we investigated the effect of piracetam on Ca(V)2.2 channels in peripheral neurons, using patch-clamp recordings from cultured superior cervical ganglion neurons. | Piracetam | calcium voltage-gated channel subunit alpha1 B | Homo sapiens |
| 3 | In addition, we tested if Ca(V)2.2 channel inhibition could be related with the effects of piracetam on central neurons. | Piracetam | calcium voltage-gated channel subunit alpha1 B | Homo sapiens |
| 4 | We found that piracetam inhibited native Ca(V)2.2 channels in superior cervical ganglion neurons in a dose-dependent manner, with an IC(50) of 3.4 mumol/L and a Hill coefficient of 1.1. | Piracetam | calcium voltage-gated channel subunit alpha1 B | Homo sapiens |
| 5 | Piracetam altered the biophysical characteristics of Ca(V)2.2 channel such as facilitation ratio. | Piracetam | calcium voltage-gated channel subunit alpha1 B | Homo sapiens |