Pub. Date : 2012
PMID : 23029230
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury. | rhodioloside | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | The aim of this study was to investigate the effects of salidroside, a phenolic glycoside with potent anti-apoptotic properties, on behavioral and histological outcomes, brain edema, and apoptosis following experimental TBI and the possible involvement of the phosphoinositide 3-kinase/protein kinase B (PI3K)/Akt signaling pathway. | rhodioloside | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Salidroside increased phosphorylation of Akt on Ser473 and the mitochondrial Bcl-2/Bax ratio at day 1, and enhanced phosphorylation of Akt on Thr308 at day 3. | rhodioloside | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | Salidroside increased phosphorylation of Akt on Ser473 and the mitochondrial Bcl-2/Bax ratio at day 1, and enhanced phosphorylation of Akt on Thr308 at day 3. | rhodioloside | thymoma viral proto-oncogene 1 | Mus musculus |
| 5 | CONCLUSIONS/SIGNIFICANCE: Post-injury salidroside improved long-term behavioral and histological outcomes and reduced brain edema and apoptosis following TBI, at least partially via the PI3K/Akt signaling pathway. | rhodioloside | thymoma viral proto-oncogene 1 | Mus musculus |