Title : Functional specialization in proline biosynthesis of melanoma.

Pub. Date : 2012

PMID : 23024808






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). Proline pyrroline-5-carboxylate reductase 1 Homo sapiens
2 Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). Proline pyrroline-5-carboxylate reductase 1 Homo sapiens
3 Based on these studies we conclude that PYCR1 and PYCR2, which are localized in the mitochondria, are primarily involved in conversion of glutamate to proline. Proline pyrroline-5-carboxylate reductase 1 Homo sapiens