Title : Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression.

Pub. Date : 2013 Jun

PMID : 23017582






3 Functional Relationships(s)
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1 Reporter assays, using the luciferase constructs containing the NAG-1 promoter, demonstrate that p53 is required for EGCG-mediated activation of NAG-1. epigallocatechin gallate tumor protein p53 Homo sapiens
2 Taken together, these results demonstrate for the first time that EGCG induces apoptosis via ATM/p53-dependent NAG-1 expression in HNSCC, providing an additional mechanistic explanation for the apoptotic activity of EGCG. epigallocatechin gallate tumor protein p53 Homo sapiens
3 Taken together, these results demonstrate for the first time that EGCG induces apoptosis via ATM/p53-dependent NAG-1 expression in HNSCC, providing an additional mechanistic explanation for the apoptotic activity of EGCG. epigallocatechin gallate tumor protein p53 Homo sapiens