Title : RSK2(Ser227) at N-terminal kinase domain is a potential therapeutic target for multiple myeloma.

Pub. Date : 2012 Dec

PMID : 23012246






1 Functional Relationships(s)
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1 RSK2(Ser227) inhibition resulting from BI-D1870 treatment restored lenalidomide-induced direct cytotoxicity of myeloma cells from interleukin-6-mediated cell protection, showed no cross-resistance to bortezomib, and exerted additive/synergistic antiproliferative effects in conjunction with the mTOR, histone deacetylase, and BH3-mimicking BCL2/BCLX(L) inhibitors. Lenalidomide BCL2 like 1 Homo sapiens