Title : Loss of adenomatous poliposis coli-α3 integrin interaction promotes endothelial apoptosis in mice and humans.

Pub. Date : 2012 Dec 7

PMID : 23011394






3 Functional Relationships(s)
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Protein Name
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1 PA endothelial cells isolated from Apc(Min/+) demonstrated reduced survival and angiogenic responses along with a profound reduction in adhesion to laminin. Protactinium APC regulator of WNT signaling pathway Homo sapiens
2 We found that PA endothelial cells from lungs of patients with idiopathic PH have reduced APC expression, decreased adhesion to laminin, and impaired vascular tube formation. Protactinium APC regulator of WNT signaling pathway Homo sapiens
3 CONCLUSIONS: We show that APC is integral to PA endothelial cells adhesion and survival and is reduced in PA endothelial cells from PH patient lungs. Protactinium APC regulator of WNT signaling pathway Homo sapiens