Title : 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

Pub. Date : 2012 Oct 25

PMID : 23006064






1 Functional Relationships(s)
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1 We describe herein the discovery of arylidene thioxothiazolidinone as a scaffold for potent Tdp1 inhibitors based on an initial tyrphostin lead compound 8. Tyrphostins tyrosyl-DNA phosphodiesterase 1 Homo sapiens