Title : Marine sponge steroids as nuclear receptor ligands.

Pub. Date : 2012 Nov

PMID : 23000093






2 Functional Relationships(s)
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1 Chemical, structural, and pharmacological characterization of sponge steroid libraries has allowed the identification of steroids that regulate FXR and PXR: selective FXR antagonists, FXR modulators, FXR antagonists endowed with PXR agonism, and selective PXR agonists. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 Identification of marine steroids endowed with dual FXR and PXR agonism-antagonism probably reflects the common identity of the unique ancestral precursor of these NRs. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens