Title : Regulation of glycogen synthase kinase-3 beta (GSK-3β) by the Akt pathway in gliomas.

Pub. Date : 2012 Nov

PMID : 22999562






1 Functional Relationships(s)
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1 We have shown in this study that GSK-3beta regulation by phosphorylation is important for cell morphology and growth, and that LiCl enhances growth of U87MG and U87MG.Delta2-7 cells by inhibiting GSK-3beta through its phosphorylation, whereas AktX reduces growth via activation of GSK-3beta by inhibiting Akt"s kinase activity. Lithium Chloride AKT serine/threonine kinase 1 Homo sapiens