Title : A small RNA derived from RNA coactivator SRA blocks steroid receptor signaling via inhibition of Pus1p-mediated pseudouridylation of SRA: evidence of a novel RNA binding domain in the N-terminus of steroid receptors.

Pub. Date : 2012 Oct 16

PMID : 22998747






1 Functional Relationships(s)
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1 Finally, we show that STR5 specifically inhibits ERalpha- and AR-dependent transactivation of target genes in steroid-sensitive cancer cells, consistent with disruption of the targeted Pus1p-SRA pathway. Steroids estrogen receptor 1 Homo sapiens