Title : Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesis.

Pub. Date : 2013 Apr 1

PMID : 22998676






1 Functional Relationships(s)
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1 RESULTS: Similar to the TOP2-targeting drug, etoposide (VP-16), the NO-donor, S-nitrosoglutathione (GSNO), induces skin melanomas formation in 7,12-dimethyl- benz[a]anthracene (DMBA)-initiated mice. Etoposide host cell factor C1 Homo sapiens