Title : Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?

Pub. Date : 2012 Nov-Dec

PMID : 22989944






2 Functional Relationships(s)
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1 Here we show that ZD7288 inhibits not only HCN channel currents, but also Na(+) currents in DRG neurons and ZD7288 was confirmed to inhibit Na(+) current in HEK293 cells transfected with Na(v)1.4 plasmids. ICI D2788 immunoglobulin lambda variable 2-14 Homo sapiens
2 Here we show that ZD7288 inhibits not only HCN channel currents, but also Na(+) currents in DRG neurons and ZD7288 was confirmed to inhibit Na(+) current in HEK293 cells transfected with Na(v)1.4 plasmids. ICI D2788 immunoglobulin lambda variable 2-14 Homo sapiens