Pub. Date : 2013 Feb
PMID : 22987284
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury. | Floxacillin | major histocompatibility complex, class I, B | Homo sapiens |
| 2 | For flucloxacillin, a delay in the reaction onset and identification of human leukocyte antigen (HLA)-B*57:01 as a susceptibility factor are indicative of an immune pathogenesis. | Floxacillin | major histocompatibility complex, class I, B | Homo sapiens |
| 3 | Thus, we characterize flucloxacillin-responsive CD4+ and CD8+ T cells from patients with liver injury and show that naive CD45RA+CD8+ T cells from volunteers expressing HLA-B*57:01 are activated with flucloxacillin when dendritic cells present the drug antigen. | Floxacillin | major histocompatibility complex, class I, B | Homo sapiens |
| 4 | Thus, we characterize flucloxacillin-responsive CD4+ and CD8+ T cells from patients with liver injury and show that naive CD45RA+CD8+ T cells from volunteers expressing HLA-B*57:01 are activated with flucloxacillin when dendritic cells present the drug antigen. | Floxacillin | major histocompatibility complex, class I, B | Homo sapiens |
| 5 | Activation of CD8+ clones with flucloxacillin was processing-dependent and restricted by HLA-B*57:01 and the closely related HLA-B*58:01. | Floxacillin | major histocompatibility complex, class I, B | Homo sapiens |
| 6 | Activation of CD8+ clones with flucloxacillin was processing-dependent and restricted by HLA-B*57:01 and the closely related HLA-B*58:01. | Floxacillin | major histocompatibility complex, class I, B | Homo sapiens |