Title : Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

Pub. Date : 2012 Nov

PMID : 22983360






2 Functional Relationships(s)
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1 COX-2-derived prostaglandin E(2) (PGE(2)) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence. Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 COX-2-derived prostaglandin E(2) (PGE(2)) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence. Reactive Oxygen Species mitochondrially encoded cytochrome c oxidase II Homo sapiens