Pub. Date : 2012 Dec 18
PMID : 22982667
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RhoA affects oral morphine analgesia depending on functional variation in intestinal P-glycoprotein induced by repeated etoposide treatment. | Morphine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | We previously reported that repeated administration of oral etoposide (ETP), an anticancer drug that is a substrate of P-glycoprotein (P-gp), caused attenuation of the analgesic effect of oral morphine through up-regulation of intestinal P-gp. | Morphine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | We previously reported that repeated administration of oral etoposide (ETP), an anticancer drug that is a substrate of P-glycoprotein (P-gp), caused attenuation of the analgesic effect of oral morphine through up-regulation of intestinal P-gp. | Morphine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | We previously reported that repeated administration of oral etoposide (ETP), an anticancer drug that is a substrate of P-glycoprotein (P-gp), caused attenuation of the analgesic effect of oral morphine through up-regulation of intestinal P-gp. | Morphine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | RhoA activation induced by repeated oral ETP administration may be involved in the up-regulation of ileal P-gp protein expression and activity, leading to a decrease in the analgesic effect of oral morphine. | Morphine | ATP binding cassette subfamily B member 1 | Homo sapiens |