Title : The oxidative denitrosylation mechanism and nitric oxide release from human fetal and adult hemoglobin, an experimentally based model simulation study.

Pub. Date : 2013 Jan

PMID : 22981699






3 Functional Relationships(s)
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1 The results show that despite the use of identical values for k22, there was a 44-fold larger apparent rate of reaction of *NO2 with HbF(NO) compared to HbA(NO), for reactions simulated at 410 muM nitrite and 100 muM hemoglobin (heme basis), 50% oxygen saturation at pH 7.4 and 37 C. This faster reaction was associated with the generation of about 11 muM peak unbound NO. Nitrogen Dioxide latexin Homo sapiens
2 The results show that despite the use of identical values for k22, there was a 44-fold larger apparent rate of reaction of *NO2 with HbF(NO) compared to HbA(NO), for reactions simulated at 410 muM nitrite and 100 muM hemoglobin (heme basis), 50% oxygen saturation at pH 7.4 and 37 C. This faster reaction was associated with the generation of about 11 muM peak unbound NO. Nitrogen Dioxide latexin Homo sapiens
3 The results show that despite the use of identical values for k22, there was a 44-fold larger apparent rate of reaction of *NO2 with HbF(NO) compared to HbA(NO), for reactions simulated at 410 muM nitrite and 100 muM hemoglobin (heme basis), 50% oxygen saturation at pH 7.4 and 37 C. This faster reaction was associated with the generation of about 11 muM peak unbound NO. Nitrogen Dioxide latexin Homo sapiens