Pub. Date : 2012 Dec
PMID : 22975449
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis. | Histamine | growth differentiation factor 15 | Homo sapiens |
| 2 | However, the role and signaling mechanism of histamine are still unclear in melanogenesis, especially in relation to growth-differentiation factor-15, which is a protein belonging to transforming growth factor beta and found to be overexpressed in metastatic or malignant melanoma. | Histamine | growth differentiation factor 15 | Homo sapiens |
| 3 | We found that histamine induces growth-differentiation factor-15 in melanoma cell lines such as SK-MEL-2, B16F10, and melan-a cells. | Histamine | growth differentiation factor 15 | Homo sapiens |
| 4 | Therefore, in the present study, the role of growth-differentiation factor-15 in histamine-induced melanogenesis was investigated using gene silencing or overexpression of growth-differentiation factor-15 and histamine related compounds such as histamine, amthamine, and cimetidine. | Histamine | growth differentiation factor 15 | Homo sapiens |
| 5 | Gene silencing of growth-differentiation factor-15 suppressed histamine-induced proliferation, melanin production, tyrosinase activity, and chemotactic migration of SK-MEL-2 cells. | Histamine | growth differentiation factor 15 | Homo sapiens |
| 6 | Histamine-induced expression of tyrosinase, tyrosinase-related protein 1, and tyrosinase-related protein 2 was also suppressed by growth-differentiation factor-15 gene silencing. | Histamine | growth differentiation factor 15 | Homo sapiens |
| 7 | Our results suggest that growth-differentiation factor-15 is a new player in histamine-induced melanogenesis, which can help researchers to extend the knowledge of the role of the transforming growth factor beta family in melanogenesis and in skin pigment disorders such as vitiligo. | Histamine | growth differentiation factor 15 | Homo sapiens |