Title : The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves.

Pub. Date : 2012 Nov

PMID : 22972661






3 Functional Relationships(s)
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1 The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Tretinoin cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus
2 In the present study, we deleted Cyp26b1, one of the RA-degrading enzymes, to further study the effects of excess RA in the normal developing palate and to understand how endogenous levels of RA are regulated. Tretinoin cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus
3 The regulation of RA signaling through CYP26B1 is also necessary for the development of tongue musculature and for tongue depression. Tretinoin cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus